Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Cisplatin and other platinum(II) analogs are widely used in clinical practice as anti-cancer drugs for a wide range of tumors. The primary mechanism by which they exert their action is through the formation of adducts with genomic DNA. However, multiple cellular targets by platinum(II) complexes hav...

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Hauptverfasser:	Nuno Martinho, Tânia C. B. Santos, Helena F. Florindo, Liana C. Silva
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2019-01-01
Schriftenreihe:	Frontiers in Physiology
Schlagworte:	cisplatin mechanism of action chemotherapeutic membrane biophysical properties membrane fluidity membrane interactions membrane permeability
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fphys.2018.01898/full
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