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Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates

ABSTRACT Fluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 susceptible isolates (~93%) had high fluc...

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Wedi'i Gadw mewn:
Prif Awduron: Brooke D. Esquivel, Amanda Santos, Jeffrey M. Rybak, Darian J. Santana, P. David Rogers, Theodore C. White
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2026-03-01
Cyfres:mBio
Pynciau:
drug accumulation
C. auris
drug import
drug efflux
mechanisms of resistance
fluconazole
Mynediad Ar-lein:https://journals.asm.org/doi/10.1128/mbio.03957-25
Tagiau: Ychwanegu Tag
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