High transposable element expression in sarcomas is associated with increased immune infiltrates and improved outcomes including after immunotherapy

Background Response to immune checkpoint inhibition (ICI) in sarcomas is overall low and heterogeneous. Understanding determinants of ICI outcomes may improve efficacy and patient selection. Thus, we investigated whether the expression of transposable elements (TEs), which are epigenetically silence...

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Autori principali:	Robert G Maki, Martina Bradic, Sandra P D’Angelo, Mrinal M Gounder, Evan Rosenbaum, Cristina R Antonescu, Allison L Richards, Ciara M Kelly, Jason E Chan, Ping Chi, Mark A Dickson, Mary L Keohan, Sujana Movva, Viswatej Avutu, Samuel Singer, William D Tap, Lauren B Banks, Benjamin A Nacev, Hyung Jun Woo, Emily K Slotkin, Travis Adamson, Mark TA Donoghue
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMJ Publishing Group 2025-09-01
Serie:	Journal for ImmunoTherapy of Cancer
Accesso online:	https://jitc.bmj.com/content/13/9/e012357.full
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