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Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling

Abstract Background There is evidence that atypical antipsychotics (APs) increase risk of osteoporosis in schizophrenia patients, however the mechanism is unclear. The aim of the study was to explore the molecular mechanisms about Wnt/β-catenin signal pathway underlying the osteal side effects of AP...

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Principais autores: Peifan Li, Yiming Wang, Xingde Liu, Zhen Zhou, Jun Wang, Haiyan Zhou, Lei Zheng, Lixia Yang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-02-01
Serier:BMC Pharmacology and Toxicology
Fag:
Atypical antipsychotics
Osteoblasts
β-catenin
Bcl-2
Mcl-1
Bax
Online adgang:http://link.springer.com/article/10.1186/s40360-019-0287-9
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