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Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer’s disease using the Lumipulse platform

Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasensitive research assays, with limited data from automated clinical platforms. We a...

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Principais autores: Andrea Valera-Barrero, Francisco Martínez-Dubarbie, Armando Guerra, Sara López-García, Carmen Lage, María Rivera-Sánchez, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Guglielmo Di Molfetta, Kaj Blennow, Nicholas J. Ashton, Henrik Zetterberg, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Marta Fernández-Matarrubia
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-03-01
Colecção:Alzheimer’s Research & Therapy
Assuntos:
Glial fibrillary acidic protein (GFAP)
Plasma biomarkers
Preclinical Alzheimer’s disease
Astrocyte activation
Microglia
Lumipulse
Acesso em linha:https://doi.org/10.1186/s13195-026-02012-9
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