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Chlamydia-driven ISG15 expression dampens the immune response of epithelial cells independently of ISGylation

ABSTRACT Excessive inflammation upon Chlamydia trachomatis infection can cause severe damages in the female genital tract. This obligate intracellular bacterium develops mainly in epithelial cells, whose innate response contributes to the overall inflammatory response to infection. The ubiquitin-lik...

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Kaydedildi:
Asıl Yazarlar: Yongzheng Wu, Chang Liu, Chongfa Tang, Béatrice Niragire, Yaël Levy-Zauberman, Cindy Adapen, Thomas Vernay, Juliette Hugueny, Véronique Baud, Agathe Subtil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2024-11-01
Seri Bilgileri:mBio
Konular:
C. trachomatis
interferon stimulated gene 15 (ISG15)
innate defense
epithelial cells
inflammation
ISGylation
Online Erişim:https://journals.asm.org/doi/10.1128/mbio.02401-24
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