Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19

Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad endothelial protective effects. Given these mechanisms, defibrotide has poten...

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Autors principals:	Edward Richardson, Clifton C. Mo, Eleonora Calabretta, Francesco Corrado, Mehmet H. Kocoglu, Rebecca M. Baron, Jean Marie Connors, Massimo Iacobelli, Lee-Jen Wei, Emily J. Benjamin, Aaron P. Rapoport, Maribel Díaz-Ricart, Antonio José Martínez-Mellado, Carmelo Carlo-Stella, Paul G. Richardson, José M. Moraleda
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-07-01
Col·lecció:	Biomolecules
Matèries:	CAR T-cell therapy bispecific antibodies/bispecific T-cell engagers COVID-19 CRS endotheliitis endotheliopathy
Accés en línia:	https://www.mdpi.com/2218-273X/15/7/1004
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