Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study

This study aimed to establish an extended design of experiment (DoE)-in vitro in vivo correlation (IVIVC) model that defines the relationship between formulation composition, in vitro dissolution, and in vivo pharmacokinetics. Fourteen sustained-release (SR) tablets of a model drug, donepezil, were...

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Detalhes bibliográficos

Principais autores:	Da Young Lee, Soyoung Shin, Tae Hwan Kim, Beom Soo Shin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-06-01
coleção:	Pharmaceutics
Assuntos:	level A IVIVC donepezil mixture design population pharmacokinetics sustained release prediction of in vivo pharmacokinetics
Acesso em linha:	https://www.mdpi.com/1999-4923/14/6/1226
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