APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer’s disease

Abstract Background Glial responses are involved in neurodegenerative processes, with tau pathology often associated with increased glial inflammatory responses in Alzheimer’s disease (AD). The apolipoprotein E (APOE) ε4 allele, the major genetic susceptibility gene for AD, might contribute to this...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Lydia Trudel, Joseph Therriault, Arthur C. Macedo, Marcel S. Woo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Seyyed Ali Hosseini, João Pedro Ferrari-Souza, Bruna Bellaver, Pamela L. Ferreira, Tevy Chan, Yi-Ting Wang, Jaime Fernandez-Arias, Yansheng Zheng, Brandon Hall, Jenna Stevenson, Robert Hopewell, Chris Hung-Hsin Hsiao, Maxime Montembeault, Jesse Klostranec, Yasser Iturria-Medina, Paolo Vitali, Thomas K. Karikari, Andrea L. Benedet, Nicholas J. Ashton, Eduardo Zimmer, Serge Gauthier, Tharick A. Pascoal, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-11-01
Serier:	Communications Medicine
Online adgang:	https://doi.org/10.1038/s43856-025-01171-4
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!