Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy

Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of adenosine A2A receptor (A2AR) in the development of a SUDEP mouse model with relevant clinical features. Using a combined paradi...

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Principais autores:	Hai-Ying Shen, Sadie B. Baer, Raey Gesese, John M. Cook, Landen Weltha, Shayla Q. Coffman, Jie Wu, Jiang-Fan Chen, Ming Gao, Teng Ji
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	adenosine A2A receptor NTS, nucleus tractus solitarius brainstem SUDEP (sudden unexplained death in epilepsy) local field potential adenosine kinase
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2022.910535/full
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