M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis

Abstract Background Endogenous neurogenesis could promote stroke recovery. Furthermore, anti-inflammatory phenotypical microglia (M2-microglia) could facilitate Neural Stem Cell (NSC)-mediated neurogenesis following Ischemic Stroke (IS). Nonetheless, the mechanisms through which M2 microglia influen...

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Autors principals:	Qian Zhang, Yan Yi, Tiange Chen, Ying Ai, Ziyang Chen, Ganzhi Liu, Zexuan Tang, Jianwei Chen, Tao Xu, Xin Chen, Jinfang Liu, Yuguo Xia
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-04-01
Col·lecció:	Journal of Nanobiotechnology
Matèries:	Small extracellular vesicles (sEVs) Microglia Neural stem cell (NSC) Ischemic stroke (IS) Neurogenesis
Accés en línia:	https://doi.org/10.1186/s12951-025-03390-2
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