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Effects of 5′,8′-Cyclo-2′-Deoxypurines on the Base Excision Repair of Clustered DNA Lesions in Nuclear Extracts of the XPC Cell Line

Clustered DNA lesions (CDL) containing 5′,8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular repair processes. The changes in the efficiency of nuclear base excision repair (BER) were investigated using (a) two cell lines, one...

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Principais autores: Julia Kaźmierczak-Barańska, Karolina Boguszewska, Michał Szewczuk, Bolesław T. Karwowski
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-11-01
Serier:Cells
Fag:
cdA
BER
BJ
XPC
DNA repair
DNA damage
Online adgang:https://www.mdpi.com/2073-4409/10/11/3254
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