Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes

Abstract In cells, the curved clathrin structures in vesicle budding are well characterized, while the flat ones remain poorly understood. Here, we reconstitute the flat assembly of ESCRT-0 protein HRS and clathrin onto lipid membranes in vitro. HRS forms gel-like protein condensates at micromolar c...

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Hlavní autoři:	Markku Hakala, Satish Babu Moparthi, Iva Ganeva, Mehmet Gül, César Bernat-Silvestre, Carlos Marcuello, Javier Espadas, Adai Colom, Mikhail Kudryashev, Wanda Kukulski, Stéphane Vassilopoulos, Marko Kaksonen, Aurélien Roux
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-026-73132-x
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