Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning

Abstract Although feedback loops are essential in development, their molecular implementation and precise functions remain elusive. Using enhancer knockout in mice, we demonstrate that a direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor gov...

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Detalhes bibliográficos

Principais autores:	Yassine X Bouchoucha, Jürgen Reingruber, Charlotte Labalette, Michel A Wassef, Elodie Thierion, Carole Desmarquet‐Trin Dinh, David Holcman, Pascale Gilardi‐Hebenstreit, Patrick Charnay
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2013-09-01
coleção:	Molecular Systems Biology
Assuntos:	Fgf Krox20 rhombomere stochastic model transcriptional enhancer
Acesso em linha:	https://doi.org/10.1038/msb.2013.46
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