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Host biological sex directs immune control of the Plasmodium parasite liver stage in mice

IntroductionPlasmodium parasites, the causative agents of malaria, undergo a complex liver stage shaped by the spatial heterogeneity of the liver. As one of the most sexually dimorphic organs, the liver undergoes sex-specific immune responses. However, the roles of biological sex and androgens in re...

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Guardado en:
Autores principales: Caroline J. Duncombe, Alen S. Poehlman, Ethan N. Conrad, Nilasha Sen, Aaron Ayenew, Rebecca C. Blyn, GW McElfresh, Elizabeth K. K. Glennon, Kenneth Boey, Anya C. Kalata, Alexis Kaushansky, Nana Minkah, Melanie J. Shears, Sean C. Murphy
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2026-03-01
Colección:Frontiers in Immunology
Materias:
innate immunity
liver
malaria
Plasmodium
sex differences
testosterone
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1734587/full
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