SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape

Abstract SOX2 is a potent oncodriver for various squamous cancers, but the underlying mechanism is largely unknown. Here we uncover a role of SOX2 in promoting global histone acetylation in esophageal squamous cancer cells (ESCCs). Mechanistic studies reveal that SOX2 promotes global histone acetyla...

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Detalhes bibliográficos

Principais autores:	Zhen Wang, Ruofei Dai, Li Kang, Huan Yang, Zhaosu Chen, Jianzhong He, Lei Shu, Yiting Zhong, Yunfeng Zhang, Zhengyi Hua, Yuanyong Huang, Yuhan Jiang, Jiwen Li, Liyan Xu, Fei Lan, Shu-Hai Lin, Jiemin Wong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-09-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-63591-z
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