Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing luminal domain (IRE1LD) that favours the latter’s monomer...

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Hlavní autoři:	Niko Amin-Wetzel, Lisa Neidhardt, Yahui Yan, Matthias P Mayer, David Ron
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2019-12-01
Edice:	eLife
Témata:	IRE1 BiP/Grp78 endoplasmic reticulum (ER) unfolded protein response (UPR) ERdj4/DNAJB9 Chinese Hamster Ovary (CHO) cells
On-line přístup:	https://elifesciences.org/articles/50793
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