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Driver mutations in GNAQ and GNA11 genes as potential targets for precision immunotherapy in uveal melanoma patients

Uveal melanoma (UM) is the most common ocular malignancy in adults. Nearly 95% of UM patients carry the mutually exclusive mutations in the homologous genes GNAQ (amino acid change Q209L/Q209P) and GNA11 (aminoacid change Q209L). UM is located in an immunosuppressed organ and does not suffer immunoe...

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Principais autores: Sandra García-Mulero, Roberto Fornelino, Marco Punta, Stefano Lise, Mar Varela, Luis P. del Carpio, Rafael Moreno, Marcel Costa-García, Dietmar Rieder, Zlatko Trajanoski, Alena Gros, Ramón Alemany, Josep María Piulats, Rebeca Sanz-Pamplona
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2023-12-01
Serier:OncoImmunology
Fag:
GNA11
GNAQ
HLA
immunotherapy
neoantigen
uveal melanoma
Online adgang:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2261278
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