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The HPSE Gene Insulator—A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease

The HPSE gene encodes heparanase (HPSE), a key player in cancer, inflammation, and autoimmunity. We have previously identified a strong HPSE gene enhancer involved in self-regulation of heparanase by negative feedback exerted in a functional rs4693608 single-nucleotide polymorphism (SNP) dependent m...

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Principais autores: Olga Ostrovsky, Polina Baryakh, Yan Morgulis, Margarita Mayorov, Nira Bloom, Katia Beider, Avichai Shimoni, Israel Vlodavsky, Arnon Nagler
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-09-01
coleção:Cells
Assuntos:
HPSE gene
enhancer
insulator
SNPs
allogeneic HSCT
acute GVHD
Acesso em linha:https://www.mdpi.com/2073-4409/10/10/2523
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