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Extensive differential gene expression and regulation by sex in human skeletal muscle

Summary: The identification of sex-differential gene regulatory elements is essential for understanding sex-differential patterns of health and disease. We leveraged bulk and single-nucleus RNA sequencing (RNA-seq) and single-nucleus ATAC-seq data from 281 skeletal muscle biopsies to characterize se...

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Main Authors: Sarah C. Hanks, Abigail S. Mauger, Arushi Varshney, Dan L. Ciotlos, Nandini Manickam, Narisu Narisu, Alexandria J. Shumway, Peter Orchard, Michael R. Erdos, Michael D. Sweeney, Jeffrey Okamoto, Anne U. Jackson, Heather M. Stringham, Lori L. Bonnycastle, Xiang Zhou, Timo A. Lakka, Karen L. Mohlke, Jaakko Tuomilehto, Markku Laakso, Michael Boehnke, Praveen Sethupathy, Francis S. Collins, Heikki A. Koistinen, Stephen C.J. Parker, Laura J. Scott
Format: Artigo
Language:Inglês
Published: Elsevier 2025-08-01
Series:Cell Genomics
Subjects:
gene expression
chromatin accessibility
single nucleus
miRNA
gene regulation
sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X25001715
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