Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements

The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in dosing across transplant types. We hypothesized...

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Autors principals:	Mohammad Haneef Khan, Guillaume C. Onyeaghala, Armin Rashidi, Shernan G. Holtan, Alexander Khoruts, Ajay Israni, Pamala A. Jacobson, Christopher Staley
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2022-12-01
Col·lecció:	Gut Microbes
Matèries:	Beta-glucuronidase immunosuppression intestinal microbiota mycophenolate MMF transplantation
Accés en línia:	https://www.tandfonline.com/doi/10.1080/19490976.2022.2108279
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