Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway

Abstract Background Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the effects underlying the transition of NFs to CAFs in oral squamous cell car...

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Detalhes bibliográficos

Principais autores:	Yujia Wang, Yue Jing, Liang Ding, Xiaoxin Zhang, Yuxian Song, Sheng Chen, Xingxing Zhao, Xiaofeng Huang, Yumei Pu, Zhiyong Wang, Yanhong Ni, Qingang Hu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-06-01
Colecção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Oral squamous cell carcinoma Cancer-associated fibroblasts Epiregulin Transition Metastasis Invasion
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-019-1277-x
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