Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model

Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical trials in glioblastoma (GBM) patients. Ultrasound-mediated blood–brain barrier opening (UMBO) using low-intensity pulsed ultrasound improved drug delivery to the brain. We explored the safety and the efficacy...

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Asıl Yazarlar:	Mohammed H. Ahmed, Isaias Hernández-Verdin, Emie Quissac, Nolwenn Lemaire, Coralie Guerin, Lea Guyonnet, Noël Zahr, Laura Mouton, Mathieu Santin, Alexandra Petiet, Charlotte Schmitt, Guillaume Bouchoux, Michael Canney, Marc Sanson, Maïté Verreault, Alexandre Carpentier, Ahmed Idbaih
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	MDPI AG 2023-01-01
Seri Bilgileri:	Pharmaceutics
Konular:	SonoCloud GL261 mouse model ultrasound-mediated drug delivery glioblastoma immune checkpoint inhibitors
Online Erişim:	https://www.mdpi.com/1999-4923/15/2/455
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Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model

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