Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency

Germline heterozygous GATA2 mutations underlie a complex disorder characterized by bone marrow failure, immunodeficiency and high risk to develop myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Our understanding about GATA2 deficiency is limited due to the lack of relevant disease m...

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Autors principals:	Julio Castaño, Damia Romero-Moya, Yvonne Richaud-Patin, Alessandra Giorgetti
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-08-01
Col·lecció:	Stem Cell Research
Matèries:	GATA2 deficiency Induced Pluripotent stem cells Gene Editing
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1873506121002920
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