Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.

Triazoles are known for their non-toxicity, higher stability and therapeutic activity. Few nucleoside (L1, L2 and L3) and non-nucleoside 1,2,3-triazoles (L4-L14) were synthesised using click chemistry and they were screened for tumor cell cytotoxicity and proliferation. Among these triazole ligands...

Повний опис

Бібліографічні деталі

Автори:	Jerald Mahesh Kumar, Mohammed M Idris, Gunda Srinivas, Pallerla Vinay Kumar, Vuppalapaty Meghah, Mitta Kavitha, Chada Raji Reddy, Prathama S Mainkar, Biswajit Pal, Srivari Chandrasekar, Narayana Nagesh
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2013-01-01
Серія:	PLoS ONE
Онлайн доступ:	https://doi.org/10.1371/journal.pone.0070798
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!