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Case Report: Ivonescimab in EGFR-mutant lung cancer with baseline malignant pleural effusion and acquired complex resistance

BackgroundPatients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) presenting with malignant pleural effusion (MPE) at diagnosis have a poor prognosis. Options are limited after EGFR-TKI resistance. Ivonescimab, a PD-1/VEGFA bispecific antibody, is effective in advance...

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Principais autores: Zeming Mo, Honglian Jiang, Lei Zhou, Qiaoya Ren, Gang Shen, Lie Li, Xiaobin Jian, Hua Yang, Yuju Bai, Mi Meng, Sisi He
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-12-01
Serier:Frontiers in Immunology
Fag:
case report
EGFR mutation
ivonescimab
lung adenocarcinoma
malignant pleural effusion
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1725067/full
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