Therapy targeted to the NLRP3 inflammasome in chronic kidney disease
Background: The NLRP3 inflammasome is a cytoplasmic polymeric protein complex composed of the cytoplasmic sensor NLRP3, the apoptosis-related spot-like protein ASC, and the inflammatory protease caspase-1. NLRP3 activates and releases IL-1β through classical pathways, and IL-18 mediates inflammation...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Karger Publishers
2024-05-01
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| Collection: | Kidney Diseases |
| Accès en ligne: | https://beta.karger.com/Article/FullText/539496 |
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