EZH2-triggered methylation of SMAD3 promotes its activation and tumor metastasis
SMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor cancer outcomes. Thus, it is critical to understand the upstream signaling pathways that govern SMAD3 activation. Here, we report that SMAD3 underwent methylation at K53 and K333 (K53/K333) by EZH2, a process...
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| Автори: | , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Clinical Investigation
2022-03-01
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| Серія: | The Journal of Clinical Investigation |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1172/JCI152394 |
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