The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons

MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage to activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components of the MRN complex compromises cell life. Mutations in MRE11, RAD50, and NBS1 cause human genomic instability syndromes Ataxia-Telangiecta...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Mingmei Ding, Xiaobing Qing, Guangyu Zhang, Carolin Baade-Büttner, Ralph Gruber, Haizhen Lu, David O. Ferguson, Christian Geis, Zhao-Qi Wang, Zhong-Wei Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-01-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	NBS1 MRE11 Purkinje neurons cerebella neurodegeneration
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.786199/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!