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A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection

Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming followed by modifie...

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Principais autores: Felicity Hartnell, Anthony Brown, Stefania Capone, Jakub Kopycinski, Carly Bliss, Shokouh Makvandi-Nejad, Leo Swadling, Emma Ghaffari, Paola Cicconi, Mariarosaria Del Sorbo, Roberta Sbrocchi, Ilaria Esposito, Ventzislav Vassilev, Paula Marriott, Clair M. Gardiner, Ciaran Bannan, Colm Bergin, Matthias Hoffmann, Bethany Turner, Alfredo Nicosia, Antonella Folgori, Tomáš Hanke, Eleanor Barnes, Lucy Dorrell
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-01-01
Serier:Frontiers in Immunology
Fag:
HIV-1
HCV (hepatitis C virus)
vaccine
coadministration
clinical trial
conserved region
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2018.03175/full
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