Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility

Outer hair cell electromotility, driven by prestin, is essential for mammalian cochlear amplification. Here, the authors report the cryo-EM structures of thermostabilized prestin in the presence of various anions, providing insight into the mechanisms of mammalian cochlear amplification.

Bibliografiske detaljer

Principais autores:	Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita, Atsuhiro Tomita, Satoe Takahashi, Takafumi Shikakura, Shigehiko Hayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Kazuaki Homma, Osamu Nureki
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2022-10-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-022-34017-x
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