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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. Positron emission tomography (PET) tracers that bind to pathological tau are used in diagnosis, but there are no current therapies to eliminate these...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications Ltd 2019-03-01
Saila:eLife
Gaiak:
Sarrera elektronikoa:https://elifesciences.org/articles/45457
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