Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury

Abstract Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which its production of NO is crucial for cardiac function. However, non‐canonical roles of BH4 have been discovered recently and the cell‐specific role of cardiomyocyte BH4 in cardiac function and metabol...

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Главные авторы:	Sandy M. Chu, Lisa C. Heather, Surawee Chuaiphichai, Thomas Nicol, Benjamin Wright, Matthieu Miossec, Jennifer K. Bendall, Gillian Douglas, Mark J. Crabtree, Keith M. Channon
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2023-06-01
Серии:	Experimental Physiology
Предметы:	cardiac metabolism ischaemia–reperfusion injury tetrahydrobiopterin
Online-ссылка:	https://doi.org/10.1113/EP090795
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