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Molecular Determinants of GS-9620-Dependent TLR7 Activation.

GS-9620 is an orally administered agonist of Toll-like receptor (TLR)7 currently being evaluated in clinical studies for the treatment of chronic HBV and HIV patients. GS-9620 has shown antiviral efficacy in preclinical models of chronic hepadnavirus infection in woodchuck as well as chimpanzee. How...

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Autori principali: Indrani Rebbapragada, Gabriel Birkus, Jason Perry, Weimei Xing, HyockJoo Kwon, Stefan Pflanz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2016-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC4718629?pdf=render
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