Chromogranin B (CHGB) is dimorphic and responsible for dominant anion channels delivered to cell surface via regulated secretion

Regulated secretion is conserved in all eukaryotes. In vertebrates granin family proteins function in all key steps of regulated secretion. Phase separation and amyloid-based storage of proteins and small molecules in secretory granules require ion homeostasis to maintain their steady states, and th...

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Autori principali:	Gaya P. Yadav, Haiyuan Wang, Joke Ouwendijk, Stephen Cross, Qiaochu Wang, Feng Qin, Paul Verkade, Michael X. Zhu, Qiu-Xing Jiang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-06-01
Serie:	Frontiers in Molecular Neuroscience
Soggetti:	regulated secretory pathways cell surface anion channels dimorphic CHGB secretory granule exocytosis cryo-EM structures
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1205516/full
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