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CD8 T cell exhaustion-associated LncRNA signature reveals novel molecular subtypes and immune targets in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) presents challenges and opportunities for immunotherapy due to its intricate immune microenvironment. Exhausted CD8 T cells (CD8Tex) are pivotal in this context but are inadequately characterized in HCC. Methods We conducted single-cell analysis on...

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Principais autores: Jiahui Feng, Dezhong Yan, Lingling Jiang, Fengqian Song
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2025-10-01
coleção:Discover Oncology
Assuntos:
Exhausted CD8 T cells
Hepatocellular carcinoma
Immune microenvironment
Immunotherapy
Molecular subtype
Acesso em linha:https://doi.org/10.1007/s12672-025-03675-w
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