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Effect of Mesenchymal Stem Cells Overexpressing BMP-9 Primed with Hypoxia on BMP Targets, Osteoblast Differentiation and Bone Repair

Bone formation is driven by many signaling molecules including bone morphogenetic protein 9 (BMP-9) and hypoxia-inducible factor 1-alpha (HIF-1α). We demonstrated that cell therapy using mesenchymal stem cells (MSCs) overexpressing BMP-9 (MSCs<sup>+BMP-9</sup>) enhances bone formation in calvarial d...

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Principais autores: Jessica Emanuella Rocha Moura Paz, Leticia Faustino Adolpho, Jaqueline Isadora Reis Ramos, Rayana Longo Bighetti-Trevisan, Robson Diego Calixto, Fabiola Singaretti Oliveira, Adriana Luisa Gonçalves Almeida, Marcio Mateus Beloti, Adalberto Luiz Rosa
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-08-01
Serier:Biology
Fag:
BMP-9
bone
cell therapy
HIF-1α
hypoxia
stem cells
Online adgang:https://www.mdpi.com/2079-7737/12/8/1147
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