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Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier

The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in particular incomplete binding was observed in a mi...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Kumar Tekwani Movellan, Melanie Wegstroth, Kerstin Overkamp, Andrei Leonov, Stefan Becker, Loren B. Andreas
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2023-12-01
Rangatū:Journal of Structural Biology: X
Ngā marau:
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2590152423000065
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