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TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form.

We have demonstrated that the renal endonuclease DNaseI is up-regulated in mesangial nephritis while down-regulated during progression of the disease. To determine the basis for these reciprocal DNaseI expression profiles we analyse processes accounting for an early increase in renal DNaseI expressi...

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Autori principali: Dhivya Thiyagarajan, Ole Petter Rekvig, Natalya Seredkina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2015-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC4465975?pdf=render
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