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Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation

Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a d...

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Главные авторы: Mahmoud Darweesh, Wael Kamel, Mikhail A. Gavrilin, Göran Akusjärvi, Catharina Svensson
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019-11-01
Серии:Frontiers in Immunology
Предметы:
adenovirus
inflammasome
VA RNAI
PKR
proinflammatory cytokines
NLRP3
Online-ссылка:https://www.frontiersin.org/article/10.3389/fimmu.2019.02791/full
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