Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

Abstract Background Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors. It also can influence alternative splicing decisions through the regulation of RNAPII elongation. In this study, we investigated the ef...

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Главные авторы:	Elena A. Matveeva, Qamar M. H. Al-Tinawi, Eric C. Rouchka, Yvonne N. Fondufe-Mittendorf
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2019-02-01
Серии:	Epigenetics & Chromatin
Предметы:	Splicing RNA polymerase II Epigenetics Poly(ADP)ribose polymerase Polymerase elongation Nucleosomes
Online-ссылка:	http://link.springer.com/article/10.1186/s13072-019-0261-1
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