Targeted hyperthermia therapy (THT) using gold nanorods remodels the tumor microenvironment to sensitize murine microsatellite-stable colorectal cancer to immune checkpoint blockade

Abstract Microsatellite-stable (MSS) colorectal cancers are refractory to immune checkpoint blockade (ICB) due to limited baseline inflammation, inefficient antigen presentation, and impaired T cell priming. We investigated whether nanomaterial-enabled targeted hyperthermia therapy (THT), based on i...

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Detalhes bibliográficos

Principais autores:	Barry E. Kennedy, Julie L. Jordan, Geetha Subramanian, Kate N. Clark, Cheryl Dean, Nicholas P. Cheverie, Kelly J. Corscadden, Caitlin Gormley, Erin B. Noftall, Mark R. Hanes, Alexander Edgar, Jean S. Marshall, Carman A. Giacomantonio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Microsatellite-stable colorectal cancer Targeted hyperthermia Gold nanorods NIR light Tumor microenvironment Immune checkpoint blockade
Acesso em linha:	https://doi.org/10.1186/s12951-026-04310-8
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