A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner

Abstract ApoE-ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), linked to increased amyloid-β (Aβ) deposition in the brain. In AD mouse models, microglial expression of apoE3 reduces amyloid plaque burden through enhanced phagocytosis, whereas apoE4 is associated with...

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Hlavní autoři:	Sourav Dasadhikari, Shamasree Ghosh, Sudip Pal, Tuomas P. J. Knowles, Kanchan Garai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-04-01
Edice:	Communications Chemistry
On-line přístup:	https://doi.org/10.1038/s42004-025-01524-z
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