Sugar molecules as a physical barrier separating therapeutic antibody proteins in freeze-dried formulations: small-angle X-ray scattering insights
Abstract The paper investigates structure of freeze-dried formulations of a therapeutical monoclonal IgG1 with non-reducing disaccharides, sucrose and trehalose, as lyoprotectors. Formulations with variable sugar-to-protein ratios are manufactured using different freeze-drying protocols and post-dry...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
SpringerOpen
2025-09-01
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| Serie: | AAPS Open |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s41120-025-00120-8 |
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