Prioritizing transcriptional factors in gene regulatory networks with PageRank

Summary: Biological states are controlled by orchestrated transcriptional factors (TFs) within gene regulatory networks. Here we show TFs responsible for the dynamic changes of biological states can be prioritized with temporal PageRank. We further show such TF prioritization can be extended by inte...

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Prif Awduron:	Hongxu Ding, Ying Yang, Yuanqing Xue, Lucas Seninge, Henry Gong, Rojin Safavi, Andrea Califano, Joshua M. Stuart
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2021-01-01
Cyfres:	iScience
Pynciau:	Gene Network Molecular Biology Omics
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2589004220312141
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!