Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Abstract To investigate the interplay among OCT4, SOX2, and KLF4, the VP16 activation domain is fused to one or multiple of these factors during reprogramming. Fusion of VP16 with OCT4 and SOX2 (OvSvK) significantly increases the efficiency of induced pluripotent stem cell (iPSC) generation compared...

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Xehetasun bibliografikoak

Egile Nagusiak:	Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Wiley 2025-08-01
Saila:	Advanced Science
Gaiak:	cell cycle histone methylation OvSvK reprogramming shortened G1 phase
Sarrera elektronikoa:	https://doi.org/10.1002/advs.202415528
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