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Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization

In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kinase inhibitors, the development of resistance is in...

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Principais autores: Julia Schueler, Cordula Tschuch, Kerstin Klingner, Daniel Bug, Anne-Lise Peille, Leanne de Koning, Eva Oswald, Hagen Klett, Wolfgang Sommergruber
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-07-01
coleção:Cells
Assuntos:
NSCLC
acquired resistance
EGFR inhibition
PDX
reverse phase protein array
whole exome sequencing
Acesso em linha:https://www.mdpi.com/2073-4409/8/7/740
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