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Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway

Abstract Radioresistance was the main reason for local recurrence and metastasis of nasopharyngeal carcinoma. Tetrandrine is reported as an antitumor drug via inducing cell cycle arrest and apoptosis. In this study, the radiosensitization effects of maximum noncytotoxic doses of tetrandrine in nasop...

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Principais autores: Jun Wang, Zhouzhou Yao, Xiaoping Lai, Hongwei Bao, Yue Li, Shuaixiang Li, Lihong Chang, Gehua Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2020-10-01
Serier:Cancer Medicine
Fag:
autophagy
MEK/ERK pathway
nasopharyngeal carcinoma
radiosensitization
tetrandrine
Online adgang:https://doi.org/10.1002/cam4.3356
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