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Construction of cancer- associated fibroblasts related risk signature based on single-cell RNA-seq and bulk RNA-seq data in bladder urothelial carcinoma

BackgroundThe ability of cancer-associated fibroblasts (CAFs) to encourage angiogenesis, tumor cell spread, and increase treatment resistance makes them pro-tumorigenic. We aimed to investigate the CAF signature in Bladder urothelial carcinoma (BLCA) and, for clinical application, to build a CAF-bas...

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Tallennettuna:
Päätekijät: Yunxun Liu, Jun Jian, Ye Zhang, Lei Wang, Xiuheng Liu, Zhiyuan Chen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2023-04-01
Sarja:Frontiers in Oncology
Aiheet:
cancer-associated fibroblasts
bladder urothelial carcinoma
tumor microenvironment
immunotherapy
single-cell RNA-seq
prognosis
Linkit:https://www.frontiersin.org/articles/10.3389/fonc.2023.1170893/full
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