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Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation

Patients with chronic kidney disease (CKD) face an increased risk of early vascular aging, progressive vascular calcification, and premature death. With increasing age, mitochondrial function and mitochondrial DNA copy number (mtDNA-cn) decline. This has been identified as an independent predictor o...

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Autori principali: Angelina Schwarz, Abdul Rashid Qureshi, Leah Hernandez, Lars Wennberg, Annika Wernerson, Karolina Kublickiene, Paul G. Shiels, Roberta Filograna, Peter Stenvinkel, Anna Witasp
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-06-01
Serie:Cells
Soggetti:
CKD
early vascular calcification
mtDNA copy number
renal transplantation
CAC score
Accesso online:https://www.mdpi.com/2073-4409/14/12/917
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